Some of these pictures and descriptions may give away plot details that you might not want to know before watching the film.
This is based on a Nathaniel Hawthorne story, starring Vincent Price as a demented scientist whose wife left him so he left his job and locked himself away from the world with his daughter Beatrice, played by Joyce Taylor. To protect Beatrice from the evils of the world that made his wife leave him, Price innoculates her with a serum he makes from the poison of a deadly plant that burns anything it touches, and this makes her kill any living thing she touches. She calls herself "the most deadly thing that was ever given life." A young medical student, Giovanni, converses with her from his window and eventually sneaks into her private garden, but she tells him he will die if he touches her. He doesn't believe it, so to prove it to him, she finds a fence lizard in the garden and tells him she will kill it with her touch. She grabs it with her hand and it starts to smoke, then it dies and turns blue. She carries it to Giovanni and asks him if he still wants to hold her. That changes his mind, but after she leaves he drops a hankerchief on the lizard, picks it up and carries it away to his medical school lab where his professor tests it and tries to make an antidote for the poison.
The lizard is a real live fence lizard. It doesn't run away when the hand comes to grab it, so it might be restrained or chilled down. This is an American production from MGM Studios, probably shot in Hollywood, so I'd guess they found a local Great Basin Fence Lizard and then either killed it and painted it blue, or used a fake as a stand-in for the dead lizard.