Some of these pictures and descriptions may give away plot details that you might not want to know before watching the film.
Rango is a pet Chameleon in a glass cage who performs plays he writes with doll parts and dead crickets and his plastic palm tree until the cage suddenly flies out of the back of his owner's car and he becomes lost in the Mojave Desert, (which here is mysteriously full of Saguaro cactus which is not found anywhere in the Mojave.) He bounces off one car after another, including Hunter S. Thompson's windshield right out of the book (and movie) Fear and Loathing in Las Vegas, which is a nice touch for in-the-know adults forced to watch this PG rated movie because Johnny Depp, the voice of Rango, played Hunter S. Thompson in the film version of the book.) But I digress. Rango eventually meets up with lots of other desert creatures and some other lizards, including Beans, a Desert Iguana with hair, eyelashes and breasts so you know she's female, Bad Bill, a Gila Monster, and a Horned Lizard.
Some critics hated the fact that the characters were based on real desert creatures, rodents and birds as well as herps, but the realistic animated herps are one of the things that makes this film so much fun, along with the spaghetti western parodies and wisecracking.
One of the lizards Rango meets is Bad Bill, a Gila Monster who is one of the town boss's hired goons and a very unpleasant character.
One of the lizards Rango meets is a horned lizard named Waffles.